Functional Neuroimaging Laboratory

of the Department of Psychiatry

of the Joan and Sanford I. Weill Medical College

of Cornell University

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Selected Publications

 

Silbersweig D, Stern E, Frith CD, Cahill C, Schnorr L, Grootoonk S, Spinks T, Clark J, Frackowiak R, Jones T.  Detection of thirty-second cognitive activations in single subjects with positron emission tomography: a new low dose H215O regional cerebral blood flow three-dimensional imaging technique. J Cereb Blood Flow Metab 13: 617-629, 1993

 

Silbersweig D, Stern E, Schnorr L, Frith CD, Ashburner J, Cahill C, Frackowiak R, Jones T. Imaging transient, randomly-occurring neuropsychological events in single subjects with positron emission tomography: an event-related countrate correlational analysis. J Cereb Blood Flow Metab, 14: 771-782, 1994.

 

Silbersweig DA, Stern E, Frith C,  Cahill C, Holmes A, Grootoonk S, Seaward J, McKenna P, Chua SE, Schnorr L, Jones T, Frackowiak RSJ.  A functional neuroanatomy of hallucinations in schizophrenia.  Nature, 378: 176-179, 1995.

 

Reinsel R, Veselis RA, Feshchenko VA, Di Resta GR, Mawlawi O, Beatty B, Silbersweig D, Stern E, Blasberg R, Macapinlac H, Finn R, Goldsmith S, Larson S.  Target detection and the prefrontal cortex: a PET scan study of the P300 event-related potential.  Ann NY Acad Sci, 769:393-397, 1995.

 

Engelien A, Silbersweig D, Stern E, Huber W, Frith C, Frackowiak R.  The functional anatomy of recovery from auditory agnosia - A PET study of sound categorization in a neurologic patient and normal controls.  Brain, 118: 1395-1409, 1995.

 

Eidelberg D, Ishikawa T, Moeller JR, Dhawan V, Spetsieris P, Silbersweig D, Stern E, Fazzini E, Dogali M, Beric A.  The regional metabolic correlates of surgical outcome following unilateral ventral pallidotomy for Parkinson's disease. Annals of Neurology,  39: 450-459, 1996.

 

Jones T, Silbersweig DA, Stern E, Schnorr L, Seaward J, Clark JC, Lammertsma AA, Grootoonk S.  The development of in-vivo tracer methods to obtain new information about human disease: a study of the hallucinating brain.  Eur  J  Nucl Med  , 23: 332-335, 1996.

 

Silbersweig DA and Stern E.  Functional neuroimaging of hallucinations in schizophrenia:  toward an integration of bottom-up and top-down approaches.  Molecular Psychiatry, 1: 367-375, 1996.

 

Isenberg N, Silbersweig D, Engelien A, Emmerich S, Malavade K, Beattie B, Leon A, Stern E.  Linguistic threat activates the human amygdala.  Proc Natl Acad Sci USA, 96:10456-9, 1999.

 

Blumberg H, Stern E, Ricketts S, Martinez D, De Asis J, White T, Epstein J, Isenberg N, McBride A, Kemperman I, Emmerich S, Dhawan V, Eidelberg D, Kocsis J, Silbersweig D.  Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry, 156:1986-1988, 1999.

 

Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney DS.  SPECT [I-123] Iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol Psychiatry, 47: 96-106, 2000.

 

Engelien A, Huber W, Silbersweig D, Stern E, Frith C, Doring W, Thron A, Frackowiak R. The neural correlates of ‘deaf-hearing’ in man: conscious sensory awareness enabled by attentional modulation. Brain, 123:532-45, 2000.

 

Yang Y, Engelien A, Engelien W, Xu S, Stern E, Silbersweig DA. A Silent Event-Related Functional MRI Technique for Brain Activation Studies without Interference of Scanner Acoustic Noise.  Magnetic Resonance in Medicine, 43:185-90,2000.

 

Stern E, Silbersweig DA, Chee K-Y, Holmes A, Robertson M, Trimble M, Frith CD, Frackowiak RSJ, Dolan R.  A functional neuroanatomy of tics in Tourette’s syndrome.  Arch Gen Psychiatry, 57: 741-748, 2000.

 

Yang Y, Engelien W, Pan H, Xu S, Silbersweig DA, Stern E.  A CBF-based event-related brain activation paradigm: Characterization of impulse-response function and comparison to BOLD.  Neuroimage, 12, 287-297, 2000.

 

Yang Y, Engelien W, Xu S, Silbersweig DA, Stern E.  Transit time, trailing time and cerebral blood flow during brain activation: measurement using multislice, pulsed spin-labeling perfusion imaging, Magnetic Resonance in Medicine, 44:680-685, 2000.

 

Blumberg H, Stern E, Martinez D, Ricketts S, De Asis J, White T, Epstein J, McBride A, Eidelberg D, Kocsis J, Silbersweig D.  Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry 48:1045-1052, 2000.

 

De Asis J, Stern E, Alexopoulos GS, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Silbersweig DA.  Decreased hippocampal and anterior cingulate activation in geriatric depression.  American Journal of Psychiatry 158:1321, 2001.

 

Gu H, Engelien W, Feng H, Silbersweig DA, Stern E, Yang Y.  Mapping transient, randomly occurring neuropsychological events using independent component analysis. Neuroimage, 14: 1432-1443, 2001.

 

Yang Y, Gu H, Zhan W, Xu S, Silbersweig DA, Stern E. Simultaneous perfusion and BOLD imaging using reversed spiral scanning at 3T: characterization of functional contrasts and susceptibility artifacts. Magn. Reson. Med., 48:278-89, 2002.

 

Engelien A, Yang Y, Engelien W, Zonana J, Stern E, Silbersweig DA.  Physiological Mapping of Human Auditory Cortices with a Silent Event-Related fMRI Technique.  Neuroimage, 16:944-953, 2002.

 

Gu H, Feng H, Zhan W, Silbersweig DA, Stern E, Yang Y.  Single-shot interleaved Z-Shim EPI with optimized compensation for signal losses due to susceptibility-induced field inhomogeneity at 3T. NeuroImage 17:1358-64, 2002.

 

Zhan W, Gu H, Silbersweig DA, Stern E, Yang Y.  Inversion profiles of adiabatic inversion pulses for flowing spins: the effects on labeling efficiency and labeling accuracy in perfusion imaging with pulsed arterial spin-labeling. Magn. Reson. Imag., 20:487-94, 2002.

 

Zhan W, Gu H, Xu S, Silbersweig DA, Stern E, Yang Y.  Circular spectrum mapping for intravoxel fiber structures based on high angular resolution apparent diffusion coefficients.  Magn. Reson. Med.,  49: 1077-88, 2003.

 

Beutel M, Stern E, Silbersweig DA.  The emerging dialogue between psychoanalysis and neuroscience: neuroimaging perspectives.  J Am Psychoanalytic Assn. 51: 773-801, 2003.

 

Tuscher O, Silbersweig D, Smith T, Pan H, Beutel M, Zonana J, Erbesh V, Weisholtz D, Stern E, A. Engelien. Processing of environmental sounds in schizophrenic patients: disordered recognition and lack of semantic specificity, Schizophrenia Research, 73: 291-295, 2005.

 

Protopopescu X, Tuescher O, Pan H, Goldstein M, Cloitre M, Gorman J, Ledoux JE, Engelien W, Silbersweig D, Stern E. Differential time-courses and specificity of amygdala activation in PTSD subjects and normal controls. Biological Psychiatry, 57: 464-473, 2005.

 

Yang Y, Gu H, Silberweig DA, Stern E. Simultaneous perfusion and BOLD measurements using single-shot interleaved Z-shim echo-planar imaging (SSIZS-EPI). Magnetic Resonance in Medicine, 53: 1207-1211, 2005.

 

Sigman M, Pan H, Yang Y, Stern E, Silbersweig D, Gilbert C.  Large scale reorganization of activity in the visual pathway with training on object recognition. Neuron 46: 823-35, 2005.

 

Butler T, Pan H, Epstein J, Protopopescu X, Tuescher O, Goldstein M, Cloitre M, Yang Y, Phelps E, Gorman J, Ledoux J, Stern E, Silbersweig D.  Fear-related activity in subgenual anterior cingulate differs between men and women. Neuroreport 16: 1233-1236, 2005.

 

Protopopescu X, Pan H, Altemus M, Tuescher O, Polanecsky M, McEwen B, Silbersweig D, Stern E.  Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proc Natl Acad Sci USA (PNAS), 102(44): 16060-5, 2005.

 

Voyer D, Butler T, Cordero J, Brake B, Silbersweig D, Stern E, & Imperato-McGinley J. The Relation between Computerized and Paper-and-Pencil Mental Rotation Tasks: A Validation Study. Journal of Clinical and Experimental Neuropsychology (in press).

 

Engelien A, Tuescher O, Hermans W, Isenberg N, Eidelberg D, Frith C, Stern E, Silbersweig D.  Functional neuroanatomy of non-verbal semantic sound processing in humans.  J Neural Transmission, 113: 599–608, 2006.

 

Epstein J, Pan H, Kocsis JH, Yang Y, Butler T, Chusid J, Hochberg H, Murrough J, Strohmayer E, Stern E, Silbersweig DA.  Lack of ventral striatal response to positive stimuli in depressed versus normal subjects.  American Journal of Psychiatry 163(10): 1784-1790, 2006.

 

Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien A, Yang Y, Gorman J, LeDoux J, Silbersweig D, Stern E.  Increased brainstem volume in panic disorder: a voxel-based morphometric study. Neuroreport, 17(4): 361-363, 2006.

 

Butler T, Imperato-McGinley J, Pan H, Voyer D, Cordero J, Stern E, Silbersweig DA. Sex differences in mental rotation: Top down versus bottom up processing. NeuroImage 32: 445-456,  2006.

 

Goldstein M, Brendel G, Tuescher O, Pan H, Epstein J, Beutel M, Yang Y, Thomas K, Posner M, Levy L, Clarkin J, Kernberg O, Stern E, Silbersweig D. Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: An emotional linguistic go/no-go fMRI study. NeuroImage 36(3): 1026-1040, 2007.

 

Butler T, Imperato-McGinley J, Pan H, Voyer D, Cunningham-Bussel A, Chang L, Zhu Y, Cordero J, Stern E, Silbersweig DA. Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task. Human Brain Mapping, in press, 2007.

 

Other Publications

   

Silbersweig D.  Neurology for Psychiatrists, in Core Readings in Psychiatry, Sacks MH, Sledge WH, Warren C, eds. Washington, American Psychiatric Press, Inc, 1995, pp 435-447

 

Friston KJ, Frith CD, Fletcher P, Silbersweig DA, Cahill C, Dolan R, Liddle P, Frackowiak RSJ, Herold S. Abnormal Fronto-Temporal Interactions in Schizophrenia, in Biology of Schizophrenia and Affective Disease, Watson SJ, ed. New York, ARNMD Series, vol. 73, Raven Press, 1996.

 

Kemperman I, Silbersweig D, Stern E, Russ M.  Brain Imaging and Personality Disorders, in Brain Imaging in Clinical Psychiatry, Krishnan KRR and Doraiswamy PM, eds. New York, Marcel Dekker, Inc., 1997.

 

Silbersweig DA, Stern E.  Symptom Localization in Neuropsychiatry: a Functional Neuroimaging Approach, in Frontiers of Neurology: a Symposium in Honor of Fred Plum, Reis DJ and Posner JB, eds.  New York, Annals of The New York Academy of Sciences, 1997, pp 410-420

 

Stern E, Silbersweig D.  Neural Mechanisms Underlying Hallucinations in Schizophrenia:  The Role of Abnormal Fronto-Temporal Interactions, in The Pathogenesis of Schizophrenia: an Experimental Psychopathology Perspective,  Lenzenweger MF and Dworkin RH, eds.  Washington, D.C., American Psychological Association, 1998, pp 235-246.

 

Epstein J, Stern E, Silbersweig DA, Mesolimbic activity associated with psychosis in schizophrenia: symptom-specific PET studies, in Advancing from the ventral striatum to the extended amygdala: implications for neuropsychiatry and drug abuse, McGinty JF, ed.  New York, Annals of the New York Academy of Sciences, 1999, 877: 562-574.

 

Stern E, Silbersweig DA.   Symptom capture as a strategy for methodologic development and pathophysiologic investigation in functional neuropsychiatric imaging, in Strategies in psychiatric neuroimaging: clinical and research applications.  D. Dougherty and S Rauch, eds.  American Psychiatric Press, 2001.

 

Alexopoulos GS, Bruce ML, Silbersweig D, Stern E, Kalayam B.  Vascular Depression: A New View of Late-Onset Depression, Dialogues in Clinical Neuroscience, in press.

 

Stern E, Silbersweig DA.  Advances in functional neuroimaging methodology for the study of brain systems underlying human neuropsychological function and dysfunction.  Journal of Clinical and Experimental Neuropsychology, special issue: Neuropsychology and Functional Neuroimaging: Convergence, Advances and New Directions, Silbersweig DA and Stern E, eds, 2001.

 

Engelien A, Stern E, Silbersweig D.  Functional  neuroimaging of human central auditory processing in normal subjects and patients with neurological and neuropsychiatric disorders. Journal of Clinical and Experimental Neuropsychology, in special issue: Neuropsychology and Functional Neuroimaging: Convergence, Advances and New Directions, Silbersweig DA and Stern E, eds, 2001.

 

Silbersweig D, Stern E.  Neuropsychology and Functional Neuroimaging: Convergence, Advances and New Directions. Journal of Clinical and Experimental Neuropsychology, in special issue: Neuropsychology and Functional Neuroimaging: Convergence, Advances and New Directions, Silbersweig DA and Stern E, eds, 2001.

 

Epstein J, Stern E, Silbersweig D.  Hallucinations: exploring mechanisms from psychology to neurobiology,  in Encyclopedia of the Human Brain, Ramachandran, ed, Elsevier Science, 2002.

 

Engelien A, Stern E, Isenberg N, Engelien W, Frith C, Silbersweig D.  The parahippocampal region and auditory-mnemonic processing. Annals of the New York Academy of Sciences, 911:477-85, 2000.

 

Epstein J, Stern E, Silbersweig D. Neuropsychiatry at the millenium: the potential for mind/brain integration through emerging interdisciplinary research strategies. Clinical Neuroscience Research: 1, 10-18, 2001.

 

Silbersweig D.  Toward a neurobiology of psychiatry at the millennium. Clinical Neuroscience Research: 1, 9, 2001.

 

Epstein J, Isenberg N, Stern E, Silbersweig D.  Toward a neuroanatomical understanding of psychiatric illness: the role of functional imaging, in Defining Psychopathology in the 21st Century (DSM-V and Beyond), Helzer J and Hudziak J, eds, American Psychiatric Publishing, 2002.

 

Epstein J, Stern E, Silbersweig D.  Hallucinations: A functional neuroanatomic perspective.  Concise Corsini Encyclopedia of Psychology and Behavioral Science, 2004.

 

Posner M, Rothbart M, Vizueta N, Thomas K, Levy K, Fossella J, Silbersweig D, Stern E, Clarkin J, Kernberg O.  An approach to the psychobiology of personality disorders.  Development and Psychopathology, 15:1093-106, 2003.

 

DeAsis J, Silbersweig D, Pan H, Young R, Stern E.  Neuroimaging Studies of fronto-limbic dysfunction in geriatric depression.  Clinical Neurosciences.  2: 324-330, 2003.

 

Butler T, Stern E, Silbersweig D.  Functional Neuroimaging of Tourette Syndrome: Advances and Future Directions.  In Advances in Neurology: 4th International Scientific Symposium on Tourette Syndrome (in press).

 

Brendel G and Silbersweig D.  Defining the Neurocircuitry of Borderline Personality Disorder: Functional Neuroimaging Approaches.  Development and Psychopathology, (in press).

 

Neuropsychology and Functional Neuroimaging: Convergence, Advances and New Directions, Silbersweig DA and Stern E, eds, SWETS and Zeitlinger Publishers, The Netherlands, 2001.

 

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